Friends who know something about Australia know the Australian medicine Panadol (Paracetamol, Chinese paracetamol. In particular, students who have seen doctors in Australia should feel deeply, from headaches, dizziness, nausea, colds, fever, even avian flu, Australian doctors dare to only prescribe Panadol. for you.
On the characteristics of Panadol
- Non-opium painkillers
- bring down a feve
- relieve pain
- Pregnant women can take it safely.
- Nursing mothers can take it safely.
- Baby can be taken at the behest of the doctor for more than one month
- You can buy it at the supermarket drugstore 7 / 11
Recently, a netizen posted such a post online:
Once I had a fever, a headache, a sore throat, a runny nose, and a panadol effervescent tablets the next day. I`d like to buy it again when I return home. Internet searches found that there were particularly serious side effects of the evaluation. Is it said that the side effects of Pop sensitivity are greater than those of Pop sensitivity? Is it true? The remaining five years to wash the kidney or something is particularly scary. And there`s a reason why panadol didn`t sell it in China? Is the rumor or true, I hope pharmacist friends point out one or two thank you!
Thank you for your answer. Last night, I fainted and spoke incoherent. Would you like to ask again if it is bad for the liver? Beyond the usual side effects or something. Thanks again!
Let`s take a look at the responses of some netizens:
Netizen F replied:
Panadol is paracetamol, this drug has been used safely for many years, the side effects are relatively small, otherwise how can it be OTC. Moreover, 95% of the drug was metabolized by the liver and then excreted by the kidney. The half-life is only 1 to 4 hours (the most common immediate release), residue of five years is nonsense. Taking too much of this medicine can cause a burden on the liver, but it has little effect on the kidney.
Liver toxicity is usually taken in large quantities in a short period of time. It is safe not to take more than 4G in a day. Of course, if the liver and kidney function is not good or the age is too old, it is better to be less than 3 g. In addition, children should be given according to the weight of the dose. Basically, unless you want to kill yourself or an accident, you don`t eat that much, just follow the instructions.
Netizen D replied:
It is estimated that yes, it will remain for at least five years. I took one five years ago, but now I don`t have a fever, headache, cold, runny nose.
For this kind of unilateral medicine, read the manual to eat on the line, do not need the rumors uploaded by the pipe network.
Netizen A replied:
First of all, panadol is the English trade name of GlaxoSmithKline. It is paracetamol tablets, one is 0.5g. Secondly, the paracetamol tablets mentioned by lz are compound paracetamol tablets, which contain 0.24 g paracetamol. Through these two articles, we can see that there is no safety difference between the two drugs simply from paracetamol.
Thirdly, the liver toxicity of paracetamol was dose-dependent. Paracetamol is mainly transformed into intermediate product by liver metabolizing enzyme P450, and then binds to glutathion to further metabolize and expel from kidney. When we take an acute overdose, we do not have enough glutathione in the liver, resulting in toxic intermediate products that injure the internal organs. After taking paracetamol for 4 hours, the plasma concentration exceeded 300 μ g / ml or 45 μ g / ml after 15 hours, while the plasma concentration was 120 μ g / ml or 30 μ g / ml after 4 hours.
Fourth, the half-life of paracetamol is 2 hours. Pharmacologically, after 6 ≤ 7 half-lives, the drug elimination is more than 99%, so we can know that there should be very little paracetamol residue in the body after 12 hours. As a result, five years of residual claims are not credible.
Fifth, while over-the-counter drugs are safe, they all have side effects. For side effects do not hold colored glasses, to the correct understanding, as long as according to the instructions or relevant professional guidance, are generally safe, very few adverse reactions. There is no secret that medicine should be taboo. But this does not mean that such drugs can be abused.
Finally, the friend upstairs who has not been sick for 5 years, you do not have a cold to show that you are in good health, acetaminophen can only relieve fever and analgesia, but also has no cold prevention effect. If it had been, it would have been a lot of news.
Update: FDA has just issued a warning that the dose limit for each administration is below 325mg, which is indeed a mentioned risk of liver injury. FDA recommends health care professionals discontinue prescribing and dispensing prescription combination drug products with more than 325 mg of acetaminophen to protect consumers
After checking Panadol, it was found that it was paracetamol (chemical name: paracetamol), an antipyretic and cold drug produced by GlaxoSmithKline. Indeed, this kind of paracetamol, made by Glaxo in the UK, called Panadol, has never been listed on mainland in China.
However, paracetamol was first listed by Johnson in the United States in 1955. after decades of patent period, hundreds of domestic pharmaceutical companies are also producing the most commonly used antipyretic and analgesic drugs, as well as imported American Johnson`s "Taino" and American Squibb`s "Baibuning" and so on. The drug has been listed in the United States since 1955. after the patent period has passed decades, hundreds of domestic pharmaceutical companies are also producing this antipyretic and analgesic drug, which is the most commonly used basic ingredient of cold medicine.
In the past 60 to 70 years, if a drug has all kinds of serious adverse reactions mentioned in the title, FDA in the United States will do nothing? Think about it.
Netizen C replied:
Panadol absorbs IQ. Although Panadol is relatively safe, but the drug is three-point poison, so even if it is omnipotent, do not take it for a long time or frequently.
Finally, attach the Panadol manual in Chinese and English, do not fall in love with online rumors.
[drug name] Panadol paracetamol
Acetaminophen; paracetamol; antipyretic; acetaminophen; Acetaminophen;N-acetyl-P-aminophenol
[English name] panadol/Paracetamol
[indications] used for colds and flu, fever, moderate pain such as joint pain, nerve pain, muscle pain, headache, migraine, dysmenorrhea, toothache and so on. This product is especially suitable for patients who are allergic to aspirin or are not suitable for it.
[usage and dosage] Oral: 300 ≤ 500 mg per adult, 2: 3 times a day. Children are 2: 3 years old, 50 times 100 mg, 4 6 years old 100 mg, 7 years 9 years old 150 mg, 10 years old 200 mg, over 12 years old 250 mg, and children under 1 year old avoid using them at the age of 2: 3, 50 × 100 mg, 4: 6, 100 mg, 7, 9, 200, 200 mg, over 12 years of age, 250 mg, 500 mg and below 1 year old.
[considerations]
People who are allergic to aspirin are generally not allergic to this product, but there are also patients with asthma who are allergic to aspirin, and a few of them have mild bronchspasmodic reaction after taking this product. Therefore, those who are allergic to aspirin are treated with caution.
Use with caution in pregnant women and lactating women.
If you have erythema or edema after taking this product, you should stop taking it immediately.
The general dose of adverse reactions caused less adverse reactions, less irritation to gastrointestinal tract, and did not cause gastrointestinal bleeding. But it can also cause nausea, vomiting, sweating, diarrhea and pale and other adverse reactions. Long-term massive drug use may damage both liver and kidney, especially in patients with low renal function, renal colic or acute renal failure may occur. Methemoglobin can also occur.
[taboo]
Those who are allergic to this product are prohibited.
Children under 1 year old and newborns should be avoided because of liver and renal dysfunction.
Alcohol poisoning, liver disease or toxicity hepatitis, this product has the risk of increasing liver toxicity effect, should be banned.
Renal insufficiency is disabled.
[limited dosage form] tablets, masticatory tablets, sustained-release tablets, effervescent tablets, dispersible tablets, capsules, oral solutions, drops, saccharants, granules, effervescent granules, suppositories.
[drug storage] should be kept closed in a cool and dry place.
[drug compatibility]
Patients who drink alcohol for a long time or are using other liver enzyme inducers, especially barbiturates or other antispasmodic drugs, are at risk of liver toxicity reaction.
Long-term combination with aspirin, other salicylate preparations or other non-steroidal anti-inflammatory drugs (such as cumulative dosage of 1000 grams per year for more than 3 years) can significantly increase the risk of renal toxicity.
When combined with antiviral agent dovudine, toxicity will be increased and should be avoided at the same time.
